| selasa januari 22 - 04:27 |  MXL Xicuahua [87] | 3-0 | Piedras Negras [35] |
| selasa januari 22 - 06:17 | San Cristóbal #2 [9] | 4-1 | MXL Academia SC [39] |
| selasa januari 22 - 09:41 | MXL Luneng Taishan [97] | 6-0 | MXL Shandong Linyi [54] |
| selasa januari 22 - 14:22 | MXL Guajos University [75] | 1-1 | MXL The Red Devils 1878 [76] |
| selasa januari 22 - 14:26 | America [83] | 4-0 | River Plate Mex [27] |
| selasa januari 22 - 16:28 | MXL Shandong Jinan [70] | 2-0 | Boca del Río [9] |
| selasa januari 22 - 17:18 | Chiapas [35] | 1-2 | Zacatepec FC [42] |
| selasa januari 22 - 18:42 | MXL Marin [42] | 2-4 | Poza Rica de Hidalgo [38] |
| selasa januari 22 - 19:35 | Los Reyes la Paz [2] | 0-4 | Reynosa #2 [45] |
