| wednesday june 22 - 01:28 |  Alegale United [12] | 3-3 | Talca #2 [12] |
| wednesday june 22 - 01:30 | Puente Alto #4 [12] | 10-2 | Quillota [4] |
| wednesday june 22 - 13:24 | Quilpué #2 [36] | 0-1 | General Velásquez FC [34] |
| wednesday june 22 - 16:50 | Red Bull NextGen [71] | 4-0 | Cultural-Obrero [64] |
| wednesday june 22 - 17:23 | Castro [53] | 5-2 | FC Spartacus [39] |
| wednesday june 22 - 18:45 | Casillero Del Diablo [63] | 0-5 | CSD Colo-Colo [93] |
| wednesday june 22 - 20:24 | Liverpool Wanderers [43] | 2-3 | Luis Cruz Martínez [74] |
| wednesday june 22 - 22:15 | Union Club [68] | 4-1 | Villa Alemana [48] |
| wednesday june 22 - 22:47 | Valdivia [16] | 0-5 | La Unión [93] |
