| friday december 22 - 01:19 |  Atletico Xàtiva [7] | 3-2 | FC Murcia #3 [5] |
| friday december 22 - 09:22 | Real Lucena #2 [6] | 2-0 | Atletico Algeciras #5 [4] |
| friday december 22 - 10:46 | Real Tarragona [16] | 2-2 | Real Algeciras #4 [11] |
| friday december 22 - 13:25 | Aranda de Duero [8] | 3-1 | FC León #5 [6] |
| friday december 22 - 13:26 | Real Eibar [8] | 2-3 | Atletico Burriana [9] |
| friday december 22 - 13:48 | Oviedo #3 [11] | 2-0 | Atletico Madrid #10 [6] |
| friday december 22 - 18:28 | RCR Tartessos [17] | 3-1 | At Gilenense [14] |
| friday december 22 - 19:32 | Real Vitoria-Gasteiz #5 [8] | 0-5 | Unión Hispana [16] |
| friday december 22 - 19:48 | Real Málaga [16] | 4-2 | Real Barcelona #5 [10] |
| friday december 22 - 20:32 | Real Sestao [9] | 2-0 | Real Badalona #4 [9] |
