| wednesday may 1 - 05:34 |  Atletico Coslada [56] | 2-1 | Real Betis [50] |
| wednesday may 1 - 09:23 | Real Salamanca #3 [13] | 0-2 | FC Gijón #4 [42] |
| wednesday may 1 - 10:44 | FC Tomelloso #2 [49] | 5-3 | Granada #2 [40] |
| wednesday may 1 - 13:28 | Vilanova i la Geltrú #2 [69] | 3-2 | FC Sevilla #5 [24] |
| wednesday may 1 - 14:41 | Galaxia Celeste [59] | 1-0 | Real Las Palmas #4 [38] |
| wednesday may 1 - 16:24 | FC Fuenlabrada #4 [34] | 1-5 | FC Leioa #2 [42] |
| wednesday may 1 - 16:26 | Atletico Tomelloso [32] | 0-5 | FC Oviedo #4 [82] |
| wednesday may 1 - 16:39 | FC Guadalajara [47] | 4-2 | València #6 [40] |
| wednesday may 1 - 16:46 | Aranda de Duero [40] | 3-1 | Real Barcelona [67] |
| wednesday may 1 - 17:40 | FC Lucena #3 [21] | 1-0 | Real Vitoria-Gasteiz #5 [19] |
